Artificial highs beyond the heights, with a loss of normal judgment, such as with overuse of chemicals, such as drugs and alcohol.
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Reckless decisions, as in irrational exuberance. (A phrase that Alan Greenspan, chairman of the Federal Reserve Board, coined to describe the Internet bubble of the 1990s.)
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Deviant behavior, as seen in mood disorders. For example, bipolar disorder, once known as manic depression, is an affective disorder defined by manic or hypomanic episodes. It's a serious illness.
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The latter example of excesses are not bad choices, but medical conditions or cultural abnormalities are. They are cited only to recognize that exuberance, while a very positive and desirable experience, can have a dark side, under curious and unusual circumstances.
For the most part, as a REAL wellness lifestyle experience and as part of a successful life, exuberance is a very good thing. It animates intellectual search, risk-taking, creativity and survival itself. There is most likely a hereditary predisposition to exuberance; neuroscientists, among others, continue to investigate the role that brain chemicals, such as dopamine, play in positive moods and psychological resilience.